In chemistry, denaturation is the process in which nucleic acids and proteins lose their structures due to external stress. Stress factors include heat, strong acids and bases, concentrated inorganic salts, organic solvents, etc. When a protein or nucleic acid is denatured, it loses some or all of its original chemical properties. By the way, did you know that when you fry an egg on the pan, you are denaturing the proteins in the egg? That’s an example of heat being the stress factor in denaturation.