From the medical standpoint it is a pill which when digested results in a lethal outcome. However from the business or political standpoint it is any stratgey used to increase negative results over positive one. For example many of those running for office tend to dig up dirt on his or opponents and use that information against them (mud slinging) another term. By introducing the negative, the person running for office hopes to poison the minds of his opponents supporters. This is not limited to the business and political arenas but can occur households as well.