Pimples are not something that will disappear overnight. There are anedontal reports that Pepsodent toothpaste can reduce or eliminate a pimple within 24 hours. There are several things you can do to prevent new ones from developing. Remove excess oil from your skin by cleaning your face daily with a cleanser. Special lotions and creams are also available to help combat acne. Unfortunately, hormones also play a part in acne. A dermatologist should be consulted when over the counter methods fail.