Kidney disease can occur without symptoms. If you are at high risk for kidney disease, such as being diabetic or have the autoimmune condition systemic lupus, it is important to visit your doctor for regular screenings. Elevated protein in the urine can cause a foamy appearance. High protein can also cause edema, especially in the face and ankles. Advanced stage kidney disease can also cause an individual to emit an unpleasant aroma from their skin, as their body tries to find another outlet for the toxins that the kidneys can no longer remove.