To open a book store, the most important thing to remember is location, location, location. Without a good location, your business will not get enough customers. Assuming you have a great location in mind, the next step is to write out your business plan. Next, you need to make a list of book wholesalers you will be using. You need to budget enough money to pay for rent and deposits on your space, display shelves for the books, a check-out area, salaries, and utilities. Then take your business plan to the bank and try to get a business start-up loan.