The most common and effective way to get rid of athletes foot is to use a antifungal cream designed to treat athletes foot. You will want to wash and dry your feet thoroughly before you apply the cream, paying special attention to the toe area. Change your sock and shoes a couple of times a day if possible. You can also buy the antifungal medicine in a spray and it is quite effective as well and easier to apply. If the athletes foot does not clear up after about two weeks of use then you need to contact your local health care for provider.