How Long to Cook Eye Round Roast?

An Eye of Round roast will take 1 3/4 to 2 1/4 hours to cook for a typical 2 to 3 pound roast. Place roast in a heavy roasting pan place in a 325 degree oven. For a rare roast, check the internal temperature and it should reach 140 degrees. Medium 160 degrees, and for well-done, 170 degrees.