How Long does Alprazolam Stay in Your System?

Alprazolam, also known as Xanax, has a half-life of 11.2 hours, which means that it takes 11.2 hours for half of the drug to leave your system. The extended release version has a half-life of 10.7 to 15.8 hours. Certain medical conditions and some medications can increase the half-life of alprazolam.